It is possible, but it will require alot of work. My friend did that to his bronco, and it took him forever.
The main thing to keep in mind is the clutch, and the crankshaft bearing install.
Before you ask any questions, a manual transmission engine has a bearing inside the end of the crankshaft that couples to the input shaft of the transmission. An automatic transmission does not have this bearing inside of the end of the crankshaft. Make sure you get one put in, they can be pressed in(it might require removal of the crankshaft
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I could be wrong about this bearing thing, but that's what my automotive class instructor told me.
Good luck......